Mutual remodeling of interacting nanodroplets and vesicles

Abstract Liquid-liquid phase separation within the cytosol leads to formation of protein-enriched droplets inside cells. These known as biomolecular condensates have ultra-low interfacial tensions and fulfill a vast range functions Biomolecular condensation can take place at plasma membrane generate mechanical forces on membranes result wetting. But little is about wetting by condensates. In this study, we utilize energy minimization explore wide parameters determine dependence phenomena tension, bending rigidity, line spontaneous curvature. We observe that interacting nanodroplets vesicles mutually remodel one another. addition, parameter regimes for which droplet-membrane systems exhibit axisymmetric non-axisymmetric contact lines. Our results provide insights into understanding intracellular processes physical mechanisms based mutual remodeling membranes.